Results of an open-label non-randomized clinical trial
Abstract
Background
Chloroquine and hydroxychloroquine are efficient on SARS-CoV-2 and Reported to be efficient in Chinese COV-19 (coronavirus )patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.
Patients and methods
French Confirmed COVID-19(coronavirus )patients were included in a single-arm protocol from early March to March 16th, to receive 600 mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical Presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. The presence and absence of virus at Day6-post inclusion was considered the endpoint.
Results
Six patients were asymptomatic (coronavirus), 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration
Then reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.
Conclusion
Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of
COVID‐19(coronavirus ): results of an open‐label non‐randomized clinical trial. International Journal of Antimicrobial Agents – In Press 17 March 2020 – DOI: 10.1016/j.ijantimicag.2020.105949 Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
Key words: 2019-nCoV; SARS-CoV-2; COVID-19; hydroxychloroquine; azithromycin;
Philippe Gautreta,b$, Jean-Christophe Lagiera,c$, Philippe Parolaa,b, Van Thuan Hoanga,b,d, Line Meddeba, Morgane Mailhea, Barbara Doudiera, Johan Courjone,f,g, Valérie Giordanengoh, Vera Esteves Vieiraa, Hervé Tissot Duponta,c, Stéphane Honoréi,j, Philippe Colsona,c, Eric Chabrièrea,c, Bernard La Scolaa,c, Jean-Marc Rolaina,c, Philippe Brouquia,c, Didier Raoulta,c*.
a
IHU-Méditerranée Infection, Marseille, France.
b
Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.
c
Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.
d
Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam
e
Infectiologie, Hôpital de l’Archet, Centre Hospitalier Universitaire de Nice, Nice, France
f
Université Côte d’Azur, Nice, France
g
U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et
Signalisation Inflammatoire, INSERM, Nice, France
h
Department of Virology, Biological and Pathological Center, Centre Hospitalier
Universitaire de Nice, 06200 Nice, France.
i
Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France
j
Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.
$
equal work
*Corresponding author:
Didier Raoult: Didier.raoult@gmail.com
About KSRA
The Kavian Scientific Research Association (KSRA) is a non-profit research organization to provide research / educational services in December 2013. The members of the community had formed a virtual group on the Viber social network. The core of the Kavian Scientific Association was formed with these members as founders. These individuals, led by Professor Siavosh Kaviani, decided to launch a scientific / research association with an emphasis on education.
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FULL Paper PDF file:
Hydroxychloroquine_final_DOI_IJAAPlease cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of
COVID‐19(coronavirus ): results of an open‐label non‐randomized clinical trial. International Journal of
Antimicrobial Agents – In Press 17 March 2020 – DOI: 10.1016/j.ijantimicag.2020.105949
Professor Siavosh Kaviani was born in 1961 in Tehran. He had a professorship. He holds a Ph.D. in Software Engineering from the QL University of Software Development Methodology and an honorary Ph.D. from the University of Chelsea.
